Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 6/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19733923 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRSLC9A1RAB9ANPC1 | |
| SCHEMBL25583358 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRSLC9A1RAB9APOLB | |
| SCHEMBL20008443 | 0.76 | SMN1; SMN2 (0.32) | SMN1; SMN2TSHRSLC9A1RAB9APOLB | |
| SCHEMBL19782622 | 0.74 | RAB9A (0.46) | SMN1; SMN2TSHRSLC9A1RAB9APOLB | |
| SCHEMBL16358826 | 0.73 | SMN1; SMN2 (0.64) | SMN1; SMN2TSHRSLC9A1RAB9ANPC1 | |
| SCHEMBL25946057 | 0.73 | SMN1; SMN2 (0.45) | SMN1; SMN2TSHRSLC9A1RAB9ANPC1 | |
| SCHEMBL13589297 | 0.72 | SMN1; SMN2 (0.52) | SMN1; SMN2TSHRSLC9A1RAB9APOLB | |
| SCHEMBL14685487 | 0.71 | RAB9A (0.45) | SMN1; SMN2TSHRSLC9A1RAB9APOLB | |
| SCHEMBL25099467 | 0.71 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRSLC9A1RAB9ANPC1 | |
| SCHEMBL24101005 | 0.71 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRSLC9A1RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |