Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 2/20 | 0.42 |
| ▸ | UBA3 | Q8TBC4 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ATG7 | O95352 | 2/20 | 0.37 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.37 |
| ▸ | UBA7 | P41226 | 1/20 | 0.37 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12567156 | 0.91 | CYP1A2 (0.45) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL18630487 | 0.86 | NAE1 (0.46) | NAE1UBA3ATG7 | |
| SCHEMBL23080227 | 0.85 | BCHE (0.36) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL1796003 | 0.83 | TRPM2 (0.53) | NAE1UBA3ATG7UBA6UBA7 | |
| SCHEMBL23080285 | 0.83 | TRPM2 (0.53) | NAE1UBA3ATG7UBA6UBA7 | |
| SCHEMBL12652414 | 0.78 | UBA6 (0.47) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL12567198 | 0.76 | ATG7 (0.46) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL17889829 | 0.75 | BCHE (0.45) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL12652415 | 0.75 | BCHE (0.45) | NAE1UBA3CYP1A2BCHEATG7 | |
| SCHEMBL13773372 | 0.74 | BCHE (0.54) | CYP1A2BCHEALDH1A1LMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | MILLENNIUM PHARMACEUTICALS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086785-A1 | SUBSTITUTED PYRROLO[2,3-D]PYRIMIDINES | TYMP, TYMS, PPA1 | NAE1 257/4885UBA3 235/4885CYP1A2 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.