Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 13/20 | 0.45 |
| ▸ | RAF1 | P04049 | 12/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008422 | 0.71 | PIK3CA (0.38) | BRAFRAF1PIK3CAROCK2ROCK1 | |
| SCHEMBL20008211 | 0.65 | BRAF (0.36) | BRAFRAF1PIK3CAPDCD1CD274 | |
| SCHEMBL20008197 | 0.64 | RAF1 (0.39) | BRAFRAF1PIK3CAROCK2ROCK1 | |
| SCHEMBL20008287 | 0.63 | RAF1 (0.44) | BRAFRAF1PIK3CD | |
| SCHEMBL20009417 | 0.63 | RAF1 (0.42) | BRAFRAF1PIK3CDROCK2ROCK1 | |
| SCHEMBL20008265 | 0.62 | RAF1 (0.43) | BRAFRAF1ROCK2ROCK1 | |
| SCHEMBL18948488 | 0.61 | NOS3 (0.43) | BRAFRAF1PIK3CA | |
| SCHEMBL20008154 | 0.60 | RAF1 (0.45) | BRAFRAF1 | |
| SCHEMBL13806000 | 0.59 | UHRF1 (0.41) | BRAFRAF1PIK3CAPIK3CDPIK3CB | |
| SCHEMBL1938188 | 0.59 | PIK3CA (0.55) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |