Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 7/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008358 | 0.77 | VRK1 (0.31) | — | |
| SCHEMBL18136476 | 0.68 | CYP2A6 (0.56) | CYP19A1CYP11B1CYP11B2CYP2A6CYP3A4 | |
| SCHEMBL20008162 | 0.66 | CRHR1 (0.35) | — | |
| SCHEMBL14934101 | 0.65 | CYP2A6 (0.56) | CYP19A1CYP11B1CYP11B2CYP2A6CYP3A4 | |
| SCHEMBL12072374 | 0.64 | CHRNB2 (0.41) | CYP3A4CYP2C9CYP2C19CYP2B6ALDH1A1 | |
| SCHEMBL18134393 | 0.63 | CYP2A6 (0.48) | CYP19A1CYP11B1CYP11B2CYP2A6CYP3A4 | |
| SCHEMBL20008535 | 0.62 | VRK1 (0.31) | — | |
| SCHEMBL29078028 | 0.61 | PDGFRB (0.56) | CYP19A1CYP11B1CYP11B2CYP2A6CYP3A4 | |
| SCHEMBL12024774 | 0.61 | PDE2A (0.49) | — | |
| SCHEMBL23812543 | 0.61 | CYP11B1 (0.50) | CYP19A1CYP11B1CYP11B2CYP2A6CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |