Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4B | O94953 | 1/20 | 0.42 |
| ▸ | KDM5C | P41229 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 3/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17526117 | 0.91 | LMNA (0.44) | LMNASMN1; SMN2NPC1RAB9AKDM4B | |
| SCHEMBL4043325 | 0.86 | LOXL2 (0.49) | KDM4BKDM5CKDM5BSYKMKNK1 | |
| SCHEMBL29427234 | 0.86 | LOXL2 (0.49) | KDM4BKDM5CKDM5BSYKMKNK1 | |
| SCHEMBL11347447 | 0.86 | LMNA (0.56) | LMNASMN1; SMN2NPC1RAB9AKDM4B | |
| SCHEMBL30893039 | 0.84 | KDM4C (0.52) | LMNASMN1; SMN2NPC1RAB9AKDM4B | |
| SCHEMBL16036217 | 0.84 | KDM4C (0.52) | LMNASMN1; SMN2NPC1RAB9AKDM4B | |
| Hydrochloric Acid SCHEMBL28122952 | 0.84 | LOXL2 (0.50) | KDM4BKDM5CKDM5BSYK | |
| Formic Acid SCHEMBL29536942 | 0.80 | SYK (0.44) | KDM4BKDM5CKDM5BSYK | |
| SCHEMBL22169023 | 0.80 | ALDH1A1 (0.44) | LMNASMN1; SMN2NPC1RAB9AKDM4B | |
| SCHEMBL26132372 | 0.80 | KDM4E (0.54) | LMNASMN1; SMN2NPC1RAB9AKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |