Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | YWHAG | P61981 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008223 | 0.69 | TP53 (0.39) | KMT2AMEN1GAACYP3A4TSHR | |
| SCHEMBL17774812 | 0.68 | HPGD (0.55) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL10126592 | 0.67 | HPGD (0.54) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL29451263 | 0.67 | HPGD (0.54) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL20008272 | 0.67 | TP53 (0.40) | KMT2AMEN1MAPTALDH1A1HTT | |
| SCHEMBL20008773 | 0.65 | CASP1 (0.42) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL22453934 | 0.63 | MEN1 (0.44) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL6761756 | 0.61 | CASP1 (0.45) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL3401840 | 0.60 | HPGD (0.55) | KMT2AMEN1MAPTTHRBALDH1A1 | |
| SCHEMBL16215495 | 0.60 | RAD52 (0.38) | KMT2AMEN1MAPTTHRBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |