Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | FUCA1 | P04066 | 2/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20420923 | 0.82 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL17897292 | 0.81 | CHRM2 (0.49) | KMT2AALDH1A1NPSR1KDM4EMEN1 | |
| SCHEMBL18705127 | 0.81 | CHRM2 (0.53) | KMT2AALDH1A1NPSR1MAPTKDM4E | |
| SCHEMBL3165425 | 0.80 | MC4R (0.48) | MAPTCHRM2CHRM4CHRM5ACHE | |
| SCHEMBL3165429 | 0.80 | MC4R (0.48) | MAPTCHRM2CHRM4CHRM5ACHE | |
| SCHEMBL19967980 | 0.79 | SLC6A9 (0.49) | KMT2AMAPTKDM4EMEN1HRH3 | |
| SCHEMBL18701025 | 0.79 | ACHE (0.49) | ALDH1A1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL11144165 | 0.77 | ACHE (0.55) | ALDH1A1MAPTHRH3CHRM2CHRM4 | |
| SCHEMBL20811168 | 0.77 | CHRM2 (0.55) | ALDH1A1MAPTCHRM2CHRM4CHRM5 | |
| SCHEMBL20797832 | 0.77 | CHRM2 (0.55) | ALDH1A1MAPTCHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180086720-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | SMARCC1, SMARCC2, SMARCA4 | KMT2A 489/4885ALDH1A1 3032/4885NPSR1 3059/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.