Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 9/20 | 0.35 |
| ▸ | BRAF | P15056 | 5/20 | 0.35 |
| ▸ | TGFB1 | P01137 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008226 | 0.77 | RAF1 (0.50) | RAF1BRAF | |
| SCHEMBL18672641 | 0.63 | TGFB1 (0.46) | TGFB1TGFBR1 | |
| SCHEMBL20009418 | 0.58 | RAF1 (0.43) | RAF1BRAF | |
| SCHEMBL22601527 | 0.57 | TGFB1 (0.41) | RAF1TGFB1TGFBR1 | |
| SCHEMBL6544405 | 0.56 | PRKCI (0.61) | — | |
| SCHEMBL18672967 | 0.56 | PRKCI (0.41) | TGFB1TGFBR1CAMK1D | |
| SCHEMBL20008523 | 0.55 | LMNA (0.34) | RAF1BRAF | |
| SCHEMBL24506584 | 0.54 | KDM4E (0.43) | TGFB1CAMK1D | |
| SCHEMBL17207212 | 0.54 | LMNA (0.48) | — | |
| SCHEMBL15071006 | 0.54 | SYK (0.42) | TGFB1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |