Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 2/20 | 0.30 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009217 | 0.71 | RAF1 (0.39) | BTKBRAF | |
| SCHEMBL20009716 | 0.69 | RAF1 (0.41) | BRAF | |
| SCHEMBL20009099 | 0.67 | — | — | |
| SCHEMBL20009265 | 0.65 | BTK (0.45) | BTKBRAFCYP2C9 | |
| SCHEMBL25732408 | 0.62 | CYP2D6 (0.40) | — | |
| SCHEMBL13951317 | 0.61 | NPC1 (0.49) | BRAFCYP2C9 | |
| SCHEMBL20008250 | 0.60 | CYP1A2 (0.34) | BRAF | |
| SCHEMBL20008773 | 0.60 | CASP1 (0.42) | CYP2C9 | |
| SCHEMBL25543568 | 0.58 | KCNK3 (0.47) | — | |
| SCHEMBL22439869 | 0.57 | NPC1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |