Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20009063 | 0.77 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL20008363 | 0.76 | MAPT (0.37) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL20008487 | 0.69 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL20009507 | 0.67 | MAPT (0.33) | MAPTALDH1A1LMNAUSP2 | |
| SCHEMBL20008164 | 0.66 | MAPT (0.32) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL20008594 | 0.65 | RAF1 (0.47) | BRAFRAF1 | |
| SCHEMBL20008383 | 0.65 | MAPT (0.38) | NPC1RAB9ASMN1; SMN2MAPTHTT | |
| SCHEMBL21391329 | 0.64 | KIT (0.60) | BRAFRAF1MAPTHTTMEN1 | |
| SCHEMBL20008387 | 0.64 | RAF1 (0.45) | BRAFRAF1 | |
| SCHEMBL3941868 | 0.63 | BRAF (0.61) | BRAFNPC1RAB9ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |