Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.30 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008179 | 0.89 | MAPT (0.31) | MAPT | |
| SCHEMBL20009447 | 0.89 | MAPT (0.33) | MAPTUSP2ALDH1A1LMNAALOX12 | |
| SCHEMBL20009505 | 0.86 | — | — | |
| SCHEMBL20008379 | 0.84 | — | — | |
| SCHEMBL20009063 | 0.81 | NPC1 (0.39) | MAPTUSP2ALDH1A1LMNAALOX12 | |
| SCHEMBL20008363 | 0.80 | MAPT (0.37) | MAPTUSP2ALDH1A1LMNAALOX12 | |
| SCHEMBL20008394 | 0.78 | RAB9A (0.33) | ALDH1A1 | |
| SCHEMBL20008388 | 0.78 | KDM4E (0.31) | — | |
| SCHEMBL20009096 | 0.78 | — | — | |
| SCHEMBL20008522 | 0.77 | MAPT (0.30) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |