Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6266160 | 0.66 | CYP2C9 (0.61) | POLBCYP2C19MEN1ALDH1A1KMT2A | |
| SCHEMBL20009505 | 0.65 | — | — | |
| SCHEMBL17540511 | 0.63 | POLB (0.55) | POLBCYP2C19P2RX7MEN1ALDH1A1 | |
| SCHEMBL10724502 | 0.63 | CYP2C9 (0.58) | CYP2C19MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL12766996 | 0.63 | HRH1 (0.40) | MEN1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL10145588 | 0.62 | CPN1 (0.47) | F2 | |
| SCHEMBL28304921 | 0.61 | ALDH1A1 (0.56) | POLBCYP2C19P2RX7MEN1ALDH1A1 | |
| SCHEMBL17247787 | 0.61 | P2RX7 (0.45) | P2RX7KMT2AL3MBTL1TDP1 | |
| SCHEMBL10243308 | 0.60 | KDM4E (0.51) | CYP2C19ALDH1A1 | |
| SCHEMBL15468517 | 0.60 | KDM4E (0.47) | CYP2C19MEN1ALDH1A1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3299367-A1 | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | Novartis AG (CH) | 2018-03-28 | — | — | EP | disclosed |