Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19995460 | 0.74 | KMT2A (0.70) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL21143451 | 0.70 | SMN1; SMN2 (0.53) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL2496934 | 0.69 | NPC1 (0.73) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL1544895 | 0.65 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6409127 | 0.64 | SMN1; SMN2 (0.80) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16944479 | 0.64 | SMN1; SMN2 (1.00) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL17712729 | 0.64 | HDAC3 (0.69) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6405090 | 0.63 | ALDH1A1 (0.72) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL19995264 | 0.62 | TSHR (0.62) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16944458 | 0.62 | SMN1; SMN2 (0.80) | ALDH1A1MEN1KMT2ASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018055627-A1 | WASP-PROTECTING SMALL MOLECULES, COMPOSITIONS, METHODS AND USES THEREOF IN THE TREATMENT OF INNATE AND ACQUIRED IMMUNE-RELATED DISORDERS OR CONDITIONS | BAR ILAN UNIVERSITY (IL) | 2018-03-29 | — | — | WO | disclosed |