Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | PAOX | Q6QHF9 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19973325 | 0.95 | SLC6A5 (0.54) | EPHX2SLC6A5RECQLGAAFAAH | |
| SCHEMBL30055020 | 0.92 | CA1 (0.44) | EPHX2SLC6A5RECQLGAATDP1 | |
| SCHEMBL20327914 | 0.87 | TSHR (0.43) | EPHX2SLC6A5RECQLGAAFAAH | |
| SCHEMBL30111127 | 0.87 | EPHX2 (0.49) | EPHX2RECQLGAAFAAHTDP1 | |
| SCHEMBL22995959 | 0.87 | SLC6A5 (0.48) | EPHX2SLC6A5RECQLGAAFAAH | |
| SCHEMBL22199737 | 0.85 | TLR2 (0.42) | EPHX2SLC6A5RECQLGAAFAAH | |
| SCHEMBL17746937 | 0.84 | KDM4E (0.49) | EPHX2SLC6A5RECQLGAAFAAH | |
| SCHEMBL540944 | 0.84 | CASP2 (0.59) | EPHX2SLC6A5GAAFAAHL3MBTL1 | |
| SCHEMBL17751908 | 0.84 | CASP2 (0.59) | EPHX2SLC6A5GAAFAAHL3MBTL1 | |
| SCHEMBL31226269 | 0.84 | KDM4E (0.49) | EPHX2SLC6A5RECQLGAAFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11358988-B2 | Immunomodulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2022-06-14 | — | — | US | disclosed |
| EP-3778622-A1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | Bristol-Myers Squibb Company (US) | 2021-02-17 | — | — | EP | disclosed |
| EP-3218392-B1 | MACROCYCLIC PEPTIDES USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2020-07-29 | — | — | EP | disclosed |
| US-20200216498-A1 | IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-07-09 | — | — | US | disclosed |
| US-10633419-B2 | Immunomodulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-04-28 | — | — | US | disclosed |
| US-20180086793-A1 | IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10633419-B2 | Immunomodulators | CD74, ICOS, HAVCR2 | EPHX2 2816/4885SLC6A5 4762/4885RECQL 1425/4885 |
| US-11358988-B2 | Immunomodulators | CD74, ICOS, HAVCR2 | EPHX2 2816/4885SLC6A5 4762/4885RECQL 1425/4885 |
| US-20180086793-A1 | IMMUNOMODULATORS | CD74, ICOS, HAVCR2 | EPHX2 2816/4885SLC6A5 4762/4885RECQL 1425/4885 |
| US-20200216498-A1 | IMMUNOMODULATORS | CD74, ICOS, HAVCR2 | EPHX2 2816/4885SLC6A5 4762/4885RECQL 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.