Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.44 |
| ▸ | CA2 | P00918 | 5/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PAOX | Q6QHF9 | 2/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20013228 | 0.92 | EPHX2 (0.48) | CA1CA2EPHX2SLC6A5TSHR | |
| SCHEMBL19973325 | 0.91 | SLC6A5 (0.54) | EPHX2SLC6A5TSHRRECQLTDP1 | |
| SCHEMBL20327914 | 0.89 | TSHR (0.43) | CA1CA2EPHX2SLC6A5TSHR | |
| SCHEMBL25030096 | 0.87 | TSHR (0.44) | CA1CA2EPHX2SLC6A5TSHR | |
| SCHEMBL23482834 | 0.87 | EPHX2 (0.45) | CA1CA2EPHX2TSHRCAPN1 | |
| SCHEMBL22967363 | 0.85 | KMT2A (0.40) | CA1CA2EPHX2CAPN1TDP1 | |
| SCHEMBL648724 | 0.84 | CYP1A2 (0.54) | CA1CA2EPHX2TSHRRECQL | |
| SCHEMBL28676999 | 0.84 | CA1 (0.56) | CA1CA2SLC6A5TSHRCAPN1 | |
| SCHEMBL25028544 | 0.84 | TLR2 (0.41) | CA1CA2EPHX2SLC6A5TSHR | |
| SCHEMBL22199737 | 0.83 | TLR2 (0.42) | CA1CA2EPHX2SLC6A5TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4087848-A1 | MULTI-FUNCTIONAL CHIMERIC MOLECULES | The Broad Institute, Inc. (US) | 2022-11-16 | — | — | EP | disclosed |