Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.56 |
| ▸ | SELL | P14151 | 1/20 | 0.52 |
| ▸ | SELP | P16109 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MPI | P34949 | 2/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20554639 | 0.85 | PIK3CA (0.45) | PIK3CASELLSELPMAPTALDH1A1 | |
| SCHEMBL11419973 | 0.83 | SELL (0.56) | PIK3CASELLSELPHDAC1MAPT | |
| SCHEMBL30132562 | 0.83 | SHBG (0.55) | PIK3CAMAPTALDH1A1SHBGLMNA | |
| SCHEMBL20554833 | 0.83 | SHBG (0.55) | PIK3CAMAPTALDH1A1SHBGLMNA | |
| SCHEMBL30132476 | 0.83 | PIK3CA (0.41) | PIK3CASELLSELPMAPTALDH1A1 | |
| SCHEMBL20554618 | 0.83 | PIK3CA (0.41) | PIK3CASELLSELPMAPTALDH1A1 | |
| SCHEMBL20554676 | 0.83 | PIK3CA (0.40) | PIK3CASELLSELPMAPTSHBG | |
| SCHEMBL7773826 | 0.82 | SELL (0.54) | PIK3CASELLSELPHDAC1MAPT | |
| SCHEMBL63797 | 0.80 | ALDH1A1 (0.55) | PIK3CASELLSELPHDAC1MAPT | |
| SCHEMBL20554382 | 0.79 | MAPT (0.42) | PIK3CAMAPTKDM4EALDH1A1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275759-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2025-12-24 | — | — | EP | disclosed |
| US-20250034126-A1 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. | 2025-01-30 | — | — | US | disclosed |
| US-12129248-B2 | Chromobox protein inhibitors and uses thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2024-10-29 | — | — | US | disclosed |
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |
| WO-2018058029-A1 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-03-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250034126-A1 | CHROMOBOX PROTEIN INHIBITORS AND USES THEREOF | CBX2, CBX3, CBX6 | PIK3CA 1092/4885SELL 4860/4885SELP 4615/4885 |
| US-12129248-B2 | Chromobox protein inhibitors and uses thereof | CBX2, CBX3, CBX6 | PIK3CA 1092/4885SELL 4860/4885SELP 4615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.