Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014376 | 0.84 | LMNA (0.46) | POLBTDP1KMT2A | |
| SCHEMBL20014667 | 0.80 | ALDH1A1 (0.44) | KDM4EPOLBTDP1ALDH1A1L3MBTL1 | |
| SCHEMBL20014681 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL14129953 | 0.77 | SCD (0.53) | KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL20014678 | 0.77 | FEN1 (0.40) | POLBTDP1FEN1 | |
| SCHEMBL5132284 | 0.77 | NPC1 (0.41) | POLBALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4318931 | 0.77 | SCD (0.52) | KDM4ETDP1ALDH1A1L3MBTL1 | |
| SCHEMBL6411852 | 0.77 | POLB (0.46) | POLBTDP1KMT2A | |
| SCHEMBL5132211 | 0.76 | AKR1B1 (0.45) | POLBALDH1A1MEN1KMT2A | |
| SCHEMBL23843697 | 0.76 | KDM4E (0.40) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2620436-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYL PYRIDONE DERIVATIVE PRODRUG | SHIONOGI & CO (JP) | 2018-05-09 | — | — | EP | disclosed |
| EP-2444400-B1 | SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE | SHIONOGI & CO (JP) | 2018-03-28 | — | — | EP | disclosed |