Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.40 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021122 | 0.88 | KDM4E (0.52) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3297610 | 0.82 | KDM4E (0.54) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3303954 | 0.81 | KDM4E (0.53) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20021157 | 0.80 | KDM4E (0.44) | KDM4ESMN1; SMN2PTGDR2 | |
| SCHEMBL20020769 | 0.79 | KDM4E (0.45) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20021110 | 0.79 | KDM4E (0.45) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3323941 | 0.79 | KDM4E (0.51) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3314187 | 0.78 | KDM4E (0.50) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20020750 | 0.78 | KDM4E (0.41) | KDM4ESMN1; SMN2 | |
| SCHEMBL3326729 | 0.77 | ACHE (0.47) | KDM4ESMN1; SMN2KCNH2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |