Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARD | Q03181 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3323941 | 0.84 | KDM4E (0.51) | KDM4ESMN1; SMN2PTGDR2LMNACA12 | |
| SCHEMBL20021165 | 0.84 | KDM4E (0.52) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3297610 | 0.81 | KDM4E (0.54) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL3303954 | 0.80 | KDM4E (0.53) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20021074 | 0.80 | KDM4E (0.44) | KDM4ESMN1; SMN2PTGDR2DHODHMEN1 | |
| SCHEMBL20020801 | 0.79 | KDM4E (0.46) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL241543 | 0.79 | PSIP1 (0.46) | VCPDHODH | |
| SCHEMBL20021122 | 0.79 | KDM4E (0.52) | KDM4ESMN1; SMN2PTGDR2LMNADHODH | |
| SCHEMBL20020731 | 0.79 | KDM4E (0.49) | KDM4ESMN1; SMN2PTGDR2LMNA | |
| SCHEMBL20020769 | 0.78 | KDM4E (0.45) | KDM4ESMN1; SMN2PTGDR2LMNACA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |