Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.47 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RGS12 | O14924 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20021094 | 0.88 | MEN1 (0.46) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL20021151 | 0.85 | MEN1 (0.44) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL10284225 | 0.84 | KDM4E (0.44) | PTGDR2PTGESALOX5KDM4EMEN1 | |
| SCHEMBL20021077 | 0.81 | CNR2 (0.44) | PTGDR2KDM4EKMT2AALDH1A1CYP3A4 | |
| SCHEMBL3297264 | 0.77 | CYP3A4 (0.42) | PTGDR2PTGESALOX5MEN1KMT2A | |
| SCHEMBL3312482 | 0.77 | PTGDR2 (0.40) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL15182599 | 0.77 | PTGES2 (0.41) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL252857 | 0.75 | PTGES2 (0.39) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL252858 | 0.75 | PTGES2 (0.39) | PTGDR2PTGESKDM4EMEN1KMT2A | |
| SCHEMBL3346070 | 0.74 | KDM4E (0.43) | PTGDR2PTGESALOX5KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588455-B1 | 2-QUINOLINYL-ACETIC ACID DERIVATIVES AS HIV ANTIVIRAL COMPOUNDS | GILEAD SCIENCES INC (US) | 2018-04-04 | — | — | EP | disclosed |