Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | ADAMTS4 | O75173 | 4/20 | 0.64 |
| ▸ | MMP2 | P08253 | 7/20 | 0.60 |
| ▸ | MMP9 | P14780 | 4/20 | 0.60 |
| ▸ | MMP3 | P08254 | 2/20 | 0.60 |
| ▸ | MMP13 | P45452 | 2/20 | 0.60 |
| ▸ | MMP1 | P03956 | 1/20 | 0.60 |
| ▸ | MMP7 | P09237 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
| ▸ | CA9 | Q16790 | 1/20 | 0.59 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.59 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29222859 | 0.93 | ALDH1A1 (0.60) | ALDH1A1POLBADAMTS4MMP2MMP9 | |
| SCHEMBL29222887 | 0.91 | ALDH1A1 (0.58) | ALDH1A1POLBADAMTS4MMP2MMP9 | |
| SCHEMBL31124612 | 0.89 | MMP2 (0.58) | ALDH1A1POLBADAMTS4MMP2MMP9 | |
| SCHEMBL29223118 | 0.89 | CNR1 (0.58) | ALDH1A1POLBADAMTS4MMP2MMP9 | |
| SCHEMBL3759433 | 0.89 | ALDH1A1 (0.73) | ALDH1A1POLBMMP2CA12CA2 | |
| SCHEMBL28426090 | 0.89 | ALDH1A1 (0.73) | ALDH1A1POLBMMP2CA12CA2 | |
| Hydrochloric Acid SCHEMBL8123779 | 0.87 | ALDH1A1 (0.71) | ALDH1A1POLBMMP2CA12CA2 | |
| SCHEMBL14619788 | 0.86 | ALDH1A1 (0.69) | ALDH1A1POLBMMP2MMP9MMP3 | |
| SCHEMBL28423968 | 0.86 | ALDH1A1 (0.69) | ALDH1A1POLBMMP2MMP9MMP3 | |
| SCHEMBL3757552 | 0.85 | ALDH1A1 (0.68) | ALDH1A1POLBADAMTS4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093960-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2018-04-05 | — | — | US | disclosed |
| US-20180093960-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093960-A1 | METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND | LDLR, APOB, NR1H2 | ALDH1A1 3152/4885POLB 2195/4885ADAMTS4 4303/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.