Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1042344 | 0.78 | ALOX5 (0.51) | ALOX5STAT3NFE2L2NFKB1NFKB2 | |
| SCHEMBL21729821 | 0.78 | PTGS2 (0.57) | ALOX5ABL1BCRPTGS2PKM | |
| SCHEMBL16052950 | 0.78 | MAPT (0.42) | NFE2L2PKMLMNAPTGS1CYP3A4 | |
| SCHEMBL29913371 | 0.77 | ABL1 (0.55) | ALOX5ABL1BCRPTGS2PKM | |
| SCHEMBL19225422 | 0.77 | ALDH1A1 (0.56) | ALOX5ABL1BCRPTGS2PKM | |
| SCHEMBL14390273 | 0.77 | ABL1 (0.55) | ALOX5ABL1BCRPTGS2PKM | |
| SCHEMBL27408256 | 0.75 | EP300 (0.47) | CA1CA2LMNACYP3A4GAA | |
| SCHEMBL10209876 | 0.75 | ALOX5 (0.64) | ALOX5PTGS2PKMCA12CA1 | |
| SCHEMBL12800877 | 0.75 | ERN1 (0.55) | ALOX5ABL1BCRPTGS2GAA | |
| SCHEMBL17744292 | 0.75 | ERN1 (0.55) | ALOX5ABL1BCRPTGS2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110036001-B | Benzo [ b ] thiophene compounds as STING agonists | 默沙东公司 | 2022-03-22 | — | — | CN | disclosed |
| US-10730849-B2 | Benzo[b]thiophene compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-04 | — | — | US | disclosed |
| US-10730849-B2 | Benzo[b]thiophene compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-08-04 | — | — | US | disclosed |
| US-10703738-B2 | Benzo[b]thiophene compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-07-07 | — | — | US | disclosed |
| US-10703738-B2 | Benzo[b]thiophene compounds as STING agonists | MERCK SHARP & DOHME CORP. (US) | 2020-07-07 | — | — | US | disclosed |
| US-20190337918-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-11-07 | — | — | US | disclosed |
| US-20190337917-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-11-07 | — | — | US | disclosed |
| US-20190337917-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2019-11-07 | — | — | US | disclosed |
| US-10414747-B2 | Benzo[b]thiophene compounds as sting agonists | MERCK SHARP & DOHME CORP. (US) | 2019-09-17 | — | — | US | disclosed |
| US-10414747-B2 | Benzo[b]thiophene compounds as sting agonists | MERCK SHARP & DOHME CORP. (US) | 2019-09-17 | — | — | US | disclosed |
| EP-3523287-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | Merck Sharp & Dohme Corp. (US) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018067423-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-12 | — | — | WO | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190337918-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
| US-10730849-B2 | Benzo[b]thiophene compounds as STING agonists | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
| US-20180093964-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
| US-10414747-B2 | Benzo[b]thiophene compounds as sting agonists | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
| US-20190337917-A1 | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
| US-10703738-B2 | Benzo[b]thiophene compounds as STING agonists | STING1, IRF3, CGAS | ALOX5 2597/4885STAT3 672/4885NFE2L2 1032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.