Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.59 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.59 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.59 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20022955 | 0.91 | HTT (0.55) | MEN1KMT2AALDH1A1L3MBTL1LMNA | |
| SCHEMBL20022977 | 0.85 | SMN1; SMN2 (0.62) | MEN1KMT2AALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL20022975 | 0.85 | L3MBTL1 (0.57) | MEN1KMT2AALDH1A1L3MBTL1MAPT | |
| SCHEMBL3979997 | 0.85 | NR1H4 (0.52) | MEN1KMT2AALDH1A1LMNAHTT | |
| SCHEMBL20022962 | 0.85 | LMNA (0.58) | KMT2AALDH1A1CYP2C19L3MBTL1CYP1A2 | |
| SCHEMBL28071194 | 0.85 | PLAU (0.64) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL20022976 | 0.83 | NPC1 (0.62) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL11057368 | 0.81 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL9976045 | 0.80 | ALDH1A1 (0.59) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL11068784 | 0.78 | MEN1 (0.61) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | ASAH2, GBA1, GAA | PLAAT3 938/4885PLAAT5 1023/4885PLAAT2 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.