Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ASPH | Q12797 | 1/20 | 0.42 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4372887 | 0.73 | RPS6KB1 (0.39) | CRHR1RPS6KB1 | |
| SCHEMBL4374877 | 0.73 | RPS6KB1 (0.39) | CRHR1RPS6KB1 | |
| SCHEMBL3952919 | 0.70 | EGFR (0.49) | KDM4EASPHKDM8CRHR1RPS6KB1 | |
| SCHEMBL4380387 | 0.70 | HTR7 (0.42) | CRHR1 | |
| SCHEMBL4381302 | 0.70 | HTR7 (0.42) | CRHR1 | |
| SCHEMBL4054099 | 0.69 | EGFR (0.48) | CRHR1RPS6KB1HDAC4HDAC1HDAC6 | |
| SCHEMBL4064799 | 0.69 | EGFR (0.48) | CRHR1RPS6KB1HDAC4HDAC1HDAC6 | |
| SCHEMBL3956498 | 0.69 | EGFR (0.48) | CRHR1RPS6KB1HDAC4HDAC1HDAC6 | |
| SCHEMBL1998196 | 0.69 | KDM4E (0.49) | KDM4EASPHKDM8 | |
| SCHEMBL28216206 | 0.69 | HSP90AA1 (0.42) | KDM4EASPHKDM8CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076878-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |