Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 3/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ASPH | Q12797 | 1/20 | 0.40 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956498 | 0.90 | EGFR (0.48) | EGFRRPS6KB1CRHR1IGF1RHDAC4 | |
| SCHEMBL4054099 | 0.90 | EGFR (0.48) | EGFRRPS6KB1CRHR1IGF1RHDAC4 | |
| SCHEMBL4064799 | 0.90 | EGFR (0.48) | EGFRRPS6KB1CRHR1IGF1RHDAC4 | |
| SCHEMBL31471043 | 0.77 | CRHR1 (0.41) | CRHR1 | |
| SCHEMBL481858 | 0.76 | EGFR (0.48) | EGFRRPS6KB1 | |
| SCHEMBL481865 | 0.76 | EGFR (0.48) | EGFRRPS6KB1 | |
| SCHEMBL481859 | 0.76 | EGFR (0.48) | EGFRRPS6KB1 | |
| SCHEMBL481775 | 0.72 | LDHB (0.57) | EGFR | |
| SCHEMBL481774 | 0.72 | LDHB (0.57) | EGFR | |
| SCHEMBL482107 | 0.72 | LDHB (0.57) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078016-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals LLC (US) | 2009-07-15 | — | — | EP | disclosed |
| WO-2008051493-A2 | HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND THEIR USE AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-05-02 | — | — | WO | disclosed |