Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ASPH | Q12797 | 2/20 | 0.51 |
| ▸ | RIOX2 | Q8IUF8 | 2/20 | 0.51 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | KDM6B | O15054 | 1/20 | 0.47 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1998196 | 0.92 | KDM4E (0.49) | TLR8TLR7KDM4EASPHRIOX2 | |
| SCHEMBL23472149 | 0.82 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL13195051 | 0.72 | TLR7 (0.68) | TLR8TLR7 | |
| SCHEMBL14869430 | 0.71 | HTR7 (0.64) | HDAC6TLR8TLR7HPGDHTR7 | |
| SCHEMBL1998194 | 0.71 | APP (0.57) | TLR8TLR7KDM4EHPGD | |
| SCHEMBL14869380 | 0.71 | HTR7 (0.68) | TLR8TLR7HPGDHTR7 | |
| SCHEMBL13194976 | 0.71 | TLR8 (0.64) | TLR8TLR7 | |
| SCHEMBL20219355 | 0.71 | TLR7 (0.64) | TLR8TLR7 | |
| SCHEMBL2571205 | 0.71 | HDAC6 (0.71) | HDAC6TLR8TLR7KDM4EASPH | |
| SCHEMBL11598417 | 0.71 | MAPT (0.64) | HDAC6HPGDKDM6BKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011076878-A1 | AMINOALKYLPYRIMIDINE DERIVATIVES AS HISTAMINE H4 RECEPTOR ANTAGONISTS | PALAU PHARMA, S.A. (ES) | 2011-06-30 | — | — | WO | disclosed |