Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.51 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4553650 | 0.86 | ALDH1A1 (0.63) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL20027937 | 0.83 | ALDH1A1 (0.60) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL3057553 | 0.81 | ALDH1A1 (0.71) | ALDH1A1HPGDSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL20027644 | 0.79 | NPC1 (0.57) | ALDH1A1SMN1; SMN2GAAMAPTRAB9A | |
| SCHEMBL1065124 | 0.77 | ALDH1A1 (0.75) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL798337 | 0.76 | ALDH1A1 (0.73) | ALDH1A1HPGDSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL900158 | 0.76 | PDE4B (0.58) | ALDH1A1HPGDSMN1; SMN2GAAMAPT | |
| SCHEMBL21357581 | 0.76 | ALDH1A1 (0.68) | ALDH1A1HPGDSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL1143334 | 0.75 | ALDH1A1 (1.00) | ALDH1A1HPGDSMN1; SMN2MAPTRAB9A | |
| SCHEMBL13887595 | 0.75 | NR4A3 (0.72) | ALDH1A1HPGDSMN1; SMN2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | ALDH1A1 4193/4885HPGD 2346/4885SMN1; SMN2 200/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | ALDH1A1 4421/4885HPGD 2414/4885SMN1; SMN2 263/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | ALDH1A1 4193/4885HPGD 2346/4885SMN1; SMN2 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.