Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | RARA | P10276 | 1/20 | 0.48 |
| ▸ | RARB | P10826 | 1/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14710561 | 0.87 | HTT (0.50) | SMN1; SMN2CYP1A2CYP2C9CYP2C19MAPT | |
| SCHEMBL19840109 | 0.86 | KMT2A (0.50) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL28811842 | 0.80 | KDR (0.47) | ALDH1A1LMNAMEN1KMT2AKDR | |
| SCHEMBL4801949 | 0.80 | KDR (0.54) | ALDH1A1LMNAMEN1KMT2AKDR | |
| SCHEMBL12727152 | 0.79 | KDR (0.53) | SMN1; SMN2CYP1A2ALDH1A1MAPTLMNA | |
| SCHEMBL4796730 | 0.77 | KDR (0.52) | CYP1A2CYP2C9CYP2C19LMNAKDR | |
| SCHEMBL6257997 | 0.77 | CYP1A2 (0.62) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20027814 | 0.77 | SMN1; SMN2 (0.55) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL20028096 | 0.77 | CYP19A1 (0.54) | CYP1A2CYP2C9CYP2C19ALDH1A1MAPT | |
| SCHEMBL5937208 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2CYP1A2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2021-03-02 | — | — | US | disclosed |
| US-10894776-B2 | — | — | 2021-01-19 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10934261-B2 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | SMN1; SMN2 200/4885CYP1A2 4836/4885CYP2C9 4860/4885 |
| US-10894776-B2 | — | CAPNS1, CAPN9, CAPN2 | SMN1; SMN2 263/4885CYP1A2 4757/4885CYP2C9 4690/4885 |
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | SMN1; SMN2 200/4885CYP1A2 4836/4885CYP2C9 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.