Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCAF1 | Q9Y4B6 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 8/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22800216 | 0.85 | DCAF1 (0.39) | DCAF1MAPTCTSVCTSLCTSS | |
| SCHEMBL22896963 | 0.81 | DCAF1 (0.53) | DCAF1KDM5BALDH1A1 | |
| SCHEMBL20028623 | 0.81 | DCAF1 (0.53) | DCAF1KDM5BALDH1A1 | |
| SCHEMBL20028241 | 0.79 | DCAF1 (0.50) | DCAF1KDM5BMAPTAURKACTSV | |
| SCHEMBL20028242 | 0.76 | DCAF1 (0.52) | DCAF1KDM5BAURKATP53ALDH1A1 | |
| SCHEMBL20028239 | 0.75 | DCAF1 (0.46) | DCAF1KDM5BMAPTAURKACTSV | |
| SCHEMBL22800154 | 0.73 | ALDH1A1 (0.46) | MAPTTP53ALDH1A1 | |
| SCHEMBL22800170 | 0.73 | KDM4E (0.43) | TP53ALDH1A1 | |
| SCHEMBL22799765 | 0.72 | MAPT (0.35) | MAPTALDH1A1 | |
| SCHEMBL22800150 | 0.72 | KDM4E (0.42) | MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | BLADE THERAPEUTICS, INC. (US) | 2022-05-24 | — | — | US | disclosed |
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11339130-B1 | Calpain modulators and therapeutic uses thereof | CAPNS1, CAPN9, CAPN1 | DCAF1 3091/4885KDM5B 4142/4885MAPT 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.