Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 3/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.42 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.42 |
| ▸ | PRKACA | P17612 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | PRKX | P51817 | 3/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.42 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22886609 | 0.93 | PYGL (0.45) | PYGLCCR1HPGDSCTSD | |
| SCHEMBL20028427 | 0.87 | PYGL (0.41) | PYGLCCR1HPGDS | |
| SCHEMBL20028424 | 0.86 | PYGL (0.40) | PYGLCCR1HPGDS | |
| SCHEMBL20028429 | 0.84 | PYGL (0.42) | PYGLCCR1HPGDSCTSD | |
| SCHEMBL21854216 | 0.83 | CAPN1 (0.52) | — | |
| SCHEMBL22886770 | 0.82 | PYGL (0.38) | PYGLROCK2ROCK1CCR1 | |
| SCHEMBL22886428 | 0.82 | PYGL (0.48) | PYGL | |
| SCHEMBL22896318 | 0.80 | CAPN1 (0.48) | — | |
| SCHEMBL22886430 | 0.78 | PYGL (0.41) | PYGLCCR1HPGDS | |
| SCHEMBL22896689 | 0.77 | CAPN1 (0.42) | CDC7DBF4ROCK2MAPK1TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |