Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841941 | 0.82 | NPSR1 (0.52) | NPSR1XDHKDM4CRNASEH1ERCC1 | |
| SCHEMBL14736371 | 0.78 | NPSR1 (0.52) | NPSR1KDM4CRNASEH1MAPTHTT | |
| SCHEMBL12697348 | 0.74 | ERCC1 (0.57) | NPSR1KDM4CRNASEH1HTTERCC1 | |
| SCHEMBL16210782 | 0.73 | KDM4C (0.42) | NPSR1XDHKDM4CMAPTHTT | |
| SCHEMBL20477252 | 0.72 | RNASEH1 (0.68) | NPSR1RNASEH1MAPTERCC1FEN1 | |
| SCHEMBL7049789 | 0.72 | NPSR1 (0.44) | NPSR1KDM4CRNASEH1MAPTERCC1 | |
| SCHEMBL27750200 | 0.72 | NPSR1 (0.44) | NPSR1KDM4CRNASEH1MAPTERCC1 | |
| SCHEMBL14602381 | 0.70 | NPSR1 (0.42) | NPSR1KDM4CRNASEH1MAPTERCC1 | |
| SCHEMBL7995185 | 0.69 | ALDH1A1 (0.51) | NPSR1MAPTHTTERCC1FEN1 | |
| SCHEMBL24596263 | 0.69 | NPSR1 (0.45) | NPSR1KDM4CMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |