Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 2/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10047206 | 0.80 | LMNA (0.46) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL22897168 | 0.80 | BACE1 (0.36) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL20033973 | 0.79 | CHRM2 (0.38) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL28911831 | 0.71 | ALDH1A1 (0.46) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL31412182 | 0.71 | BACE1 (0.48) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL25706171 | 0.70 | CHRM2 (0.51) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL887941 | 0.69 | CHRM2 (0.50) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL8890659 | 0.67 | CHRM2 (0.38) | BACE1ALOX5ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27926900 | 0.67 | TDO2 (0.47) | BACE1ALDH1A1HPGDHSD17B10BCL2L1 | |
| SCHEMBL10166444 | 0.67 | NPC1 (0.44) | BACE1ALDH1A1HPGDHSD17B10CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064119-A1 | CALPAIN MODULATORS AND THERAPEUTIC USES THEREOF | BLADE THERAPEUTICS, INC. (US) | 2018-04-05 | — | — | WO | disclosed |