Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 3/20 | 0.68 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.68 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.68 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | FPR2 | P25090 | 1/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8737718 | 0.86 | NPC1 (0.72) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL20022976 | 0.86 | NPC1 (0.62) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL16562131 | 0.84 | TAAR1 (0.68) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL1521953 | 0.83 | LTA4H (0.58) | NPC1RAB9AMAPTSMN1; SMN2ATM | |
| SCHEMBL23440104 | 0.82 | PLAAT3 (0.73) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL17919369 | 0.81 | SMN1; SMN2 (0.77) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL20023114 | 0.81 | NPC1 (0.56) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL6552601 | 0.80 | NPC1 (0.63) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL10516281 | 0.80 | SMN1; SMN2 (0.71) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL7059127 | 0.80 | PLAAT3 (0.61) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | GENZYME CORPORATION | 2018-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093981-A1 | 2-Acylaminopropoanol-Type Glucosylceramide Synthase Inhibitors | ASAH2, GBA1, GAA | PLAAT3 938/4885PLAAT5 1023/4885PLAAT2 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.