Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17547135 | 0.91 | KDM4E (0.35) | KDM4EHRH4HPGDALDH1A1HTT | |
| SCHEMBL20030918 | 0.88 | KDM4E (0.39) | KDM4ETDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL20030761 | 0.87 | KDM4E (0.36) | KDM4ETDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL20030973 | 0.86 | KDM4E (0.43) | KDM4ETDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL19906245 | 0.85 | HDAC3 (0.37) | KDM4EHRH4ALDH1A1MEN1KMT2A | |
| SCHEMBL20030976 | 0.84 | SMN1; SMN2 (0.35) | KDM4ETDP1L3MBTL1SMN1; SMN2HPGD | |
| SCHEMBL20030828 | 0.84 | BRD4 (0.34) | KDM4EHRH4HPGDMEN1KMT2A | |
| SCHEMBL31114867 | 0.84 | BRD4 (0.34) | KDM4EHRH4HPGDMEN1KMT2A | |
| SCHEMBL19906008 | 0.84 | TACR1 (0.36) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20030670 | 0.83 | L3MBTL1 (0.32) | KDM4ETDP1L3MBTL1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018064080-A1 | BENZOTHIAZOL-6-YL ACETIC ACID DERIVATIVES AND THEIR USE FOR TREATING HIV INFECTION | GILEAD SCIENCES, INC. (US) | 2018-04-05 | — | — | WO | disclosed |