Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | KDM1A | O60341 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13416043 | 0.85 | DRD2 (0.59) | DRD2ALDH1A1KMT2AMEN1 | |
| SCHEMBL27314351 | 0.84 | KDM1A (0.50) | DRD2ALDH1A1KMT2AGAAADRA1A | |
| SCHEMBL27314354 | 0.84 | KDM1A (0.50) | DRD2ALDH1A1KMT2AGAAADRA1A | |
| SCHEMBL13416035 | 0.82 | ALDH1A1 (0.53) | DRD2ALDH1A1KMT2AMEN1 | |
| SCHEMBL31268666 | 0.82 | ADRA1A (0.47) | DRD2ALDH1A1KMT2AGAAADRA1A | |
| SCHEMBL4403006 | 0.80 | DRD2 (0.68) | DRD2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL25004291 | 0.79 | ADRA1A (0.45) | DRD2ALDH1A1KMT2AGAAADRA1A | |
| SCHEMBL1515026 | 0.78 | DRD2 (0.59) | DRD2ALDH1A1KMT2AADRA1AKDM1A | |
| SCHEMBL11714356 | 0.78 | KDM1A (0.59) | DRD2ALDH1A1KMT2AADRA1AKDM1A | |
| SCHEMBL12227833 | 0.78 | KDM1A (0.59) | DRD2ALDH1A1KMT2AADRA1AKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519385-B1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LTD (GB) | 2020-11-18 | — | — | EP | disclosed |
| WO-2018060689-A1 | CYANOPYRROLIDINE DERIVATIVES WITH ACTIVITY AS INHIBITORS OF USP30 | MISSION THERAPEUTICS LIMITED (GB) | 2018-04-05 | — | — | WO | disclosed |