SCHEMBL20032413

SCHEMBL20032413

FC(F)=C(F)c1cc(F)cc(F)c1C(F)=C(F)F

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CES2 O00748 5/20 0.40
CES1 P23141 5/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23131337 0.88 CES2 (0.35) CES2CES1
SCHEMBL28294005 0.75 CES2 (0.41) CES2CES1
SCHEMBL21218738 0.73
SCHEMBL31735913 0.70 CES2 (0.36) CES2CES1
SCHEMBL21618551 0.70 CES2 (0.34) CES2CES1
SCHEMBL20032195 0.69 CES2 (0.33) CES2CES1
SCHEMBL20032455 0.69 HPGD (0.32)
SCHEMBL28295875 0.69 CES2 (0.33) CES2CES1
SCHEMBL21218724 0.68 CES2 (0.31) CES2CES1
SCHEMBL21218745 0.68 CES2 (0.31) CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3521266-B1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TOSOH FINECHEM CORP (JP) 2021-03-24 EP claimed
US-10654779-B2 Substituted bis(trifluorovinyl)benzene compound TOSOH FINECHEM CORPORATION (JP) 2020-05-19 US claimed
US-20200017429-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TOSOH FINECHEM CORPORATION (JP) 2020-01-16 US claimed
EP-3521266-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND Tosoh Finechem Corporation (JP) 2019-08-07 EP claimed
CN-109790091-A Replace bis- (trifluoro vinyl) benzene compounds 东曹精细化工株式会社 2019-05-21 CN claimed
EP-3521266-B1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TOSOH FINECHEM CORP (JP) 2021-03-24 EP disclosed
US-10654779-B2 Substituted bis(trifluorovinyl)benzene compound TOSOH FINECHEM CORPORATION (JP) 2020-05-19 US disclosed
US-10654779-B2 Substituted bis(trifluorovinyl)benzene compound TOSOH FINECHEM CORPORATION (JP) 2020-05-19 US disclosed
US-20200017429-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TOSOH FINECHEM CORPORATION (JP) 2020-01-16 US disclosed
US-20200017429-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TOSOH FINECHEM CORPORATION (JP) 2020-01-16 US disclosed
EP-3521266-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND Tosoh Finechem Corporation (JP) 2019-08-07 EP disclosed
CN-109790091-A Replace bis- (trifluoro vinyl) benzene compounds 东曹精细化工株式会社 2019-05-21 CN disclosed
WO-2018061677-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND 東ソー・ファインケム株式会社 2018-04-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10654779-B2 Substituted bis(trifluorovinyl)benzene compound TCF7L2, AFF1, TYR CES2 2706/4885CES1 2344/4885
US-20200017429-A1 SUBSTITUTED BIS(TRIFLUOROVINYL)BENZENE COMPOUND TCF7L2, AFF1, TYR CES2 2706/4885CES1 2344/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.