Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 13/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987537 | 0.85 | GLS (0.86) | GLSHSD17B10MAPK1GAAALDH1A1 | |
| SCHEMBL20033181 | 0.85 | GLS (0.73) | GLSHSD17B10MAPK1GAA | |
| SCHEMBL14987273 | 0.79 | GLS (1.00) | GLSHSD17B10MAPK1 | |
| SCHEMBL14987619 | 0.75 | GLS (1.00) | GLSHSD17B10MAPK1GAATSHR | |
| SCHEMBL21368796 | 0.73 | GLS (0.76) | GLSHSD17B10MAPK1GAATSHR | |
| SCHEMBL19754323 | 0.73 | GLS (0.56) | GLSHSD17B10MAPK1GAATSHR | |
| SCHEMBL22031503 | 0.72 | GLS (0.78) | GLSHSD17B10MAPK1 | |
| SCHEMBL21368799 | 0.69 | GLS (0.80) | GLSHSD17B10MAPK1GAATSHR | |
| SCHEMBL14987532 | 0.68 | GLS (0.49) | GLS | |
| SCHEMBL14987102 | 0.68 | GLS (1.00) | GLSHSD17B10TSHRALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938267-B2 | Heterocyclic inhibitors of glutaminase | CALITHERA BIOSCIENCES, INC. (US) | 2018-04-10 | — | — | US | disclosed |