Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 17/20 | 0.73 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14987537 | 0.92 | GLS (0.86) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL19754323 | 0.88 | GLS (0.56) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL14987273 | 0.85 | GLS (1.00) | GLSMAPK1HSD17B10 | |
| SCHEMBL20034588 | 0.85 | GLS (0.64) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL14987619 | 0.81 | GLS (1.00) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL22031503 | 0.75 | GLS (0.78) | GLSMAPK1HSD17B10 | |
| SCHEMBL21368799 | 0.74 | GLS (0.80) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL14987102 | 0.73 | GLS (1.00) | GLSHSD17B10 | |
| SCHEMBL21368796 | 0.72 | GLS (0.76) | GLSMAPK1HSD17B10GAA | |
| SCHEMBL21369061 | 0.71 | GLS (0.78) | GLSMAPK1HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938267-B2 | Heterocyclic inhibitors of glutaminase | CALITHERA BIOSCIENCES, INC. (US) | 2018-04-10 | — | — | US | disclosed |
| US-9938267-B2 | Heterocyclic inhibitors of glutaminase | CALITHERA BIOSCIENCES, INC. (US) | 2018-04-10 | — | — | US | disclosed |