Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21368799 | 0.87 | GLS (0.80) | GLSTSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14987273 | 0.86 | GLS (1.00) | GLSHSD17B10MAPK1 | |
| SCHEMBL21640563 | 0.79 | TSHR (0.57) | GLSTSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL14987537 | 0.78 | GLS (0.86) | GLSALDH1A1GAAHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL21641194 | 0.77 | TSHR (0.56) | GLSTSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL22031503 | 0.76 | GLS (0.78) | GLSHSD17B10MAPK1 | |
| SCHEMBL20034588 | 0.73 | GLS (0.64) | GLSTSHRALDH1A1SMN1; SMN2GAA | |
| SCHEMBL15727757 | 0.73 | GLS (0.67) | GLSALDH1A1SMN1; SMN2GAAPOLB | |
| SCHEMBL15200203 | 0.73 | GLS (0.71) | GLSTSHRALDH1A1GAAKDM4E | |
| SCHEMBL19754323 | 0.72 | GLS (0.56) | GLSTSHRALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2782570-B1 | HETEROCYCLIC INHIBITORS OF GLUTAMINASE | CALITHERA BIOSCIENCES INC (US) | 2019-09-18 | — | — | EP | disclosed |