Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ANPEP | P15144 | 2/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 2/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9975303 | 0.85 | RAB9A (0.43) | MAPTSMN1; SMN2KMT2ALMNAMEN1 | |
| SCHEMBL6957597 | 0.73 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL12269633 | 0.73 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL17324235 | 0.71 | — | — | |
| SCHEMBL23471188 | 0.70 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL13328238 | 0.70 | SMN1; SMN2 (0.46) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL19704374 | 0.70 | SMN1; SMN2 (0.34) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL2976450 | 0.69 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL20939040 | 0.69 | KMT2A (0.46) | MAPTSMN1; SMN2HTTKMT2ALMNA | |
| SCHEMBL8989914 | 0.69 | LMNA (0.45) | MAPTSMN1; SMN2HTTKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |