Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19698223 | 0.93 | GAA (0.33) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL18875813 | 0.93 | MEN1 (0.41) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL18875840 | 0.92 | L3MBTL1 (0.43) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL19704138 | 0.90 | SIGMAR1 (0.37) | HTTRECQLMEN1KMT2AALDH1A1 | |
| SCHEMBL20033312 | 0.90 | ALDH1A1 (0.35) | HTTMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL19704134 | 0.89 | HTT (0.38) | HTTCASP2RECQLL3MBTL1MEN1 | |
| SCHEMBL19703734 | 0.89 | TSHR (0.33) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL19704337 | 0.89 | TSHR (0.33) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL19698225 | 0.87 | L3MBTL1 (0.38) | HTTCASP2TSHRRECQLL3MBTL1 | |
| SCHEMBL19698236 | 0.85 | BRAF (0.33) | HTTMEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9938323-B2 | Amatoxin derivatives and conjugates thereof as inhibitors of RNA polymerase | NOVARTIS AG (CH) | 2018-04-10 | — | — | US | disclosed |