Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2009968 | 0.95 | MAPT (0.39) | MAPTLMNAALDH1A1ALOX12CYP1A2 | |
| SCHEMBL2002564 | 0.93 | L3MBTL1 (0.36) | L3MBTL1MAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL1996469 | 0.93 | LMNA (0.42) | MAPTLMNAALDH1A1ALOX12CYP1A2 | |
| SCHEMBL2002516 | 0.92 | L3MBTL1 (0.36) | L3MBTL1MAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL2005862 | 0.92 | MAPT (0.41) | MAPTLMNAALDH1A1PPARGS1PR3 | |
| SCHEMBL2002629 | 0.91 | PPARG (0.39) | L3MBTL1MAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL1999915 | 0.90 | L3MBTL1 (0.39) | L3MBTL1MAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL2008306 | 0.89 | L3MBTL1 (0.43) | L3MBTL1MAPTLMNAALDH1A1ALOX12 | |
| SCHEMBL2006531 | 0.89 | PLA2G2A (0.41) | MAPTLMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL2005435 | 0.89 | F2RL3 (0.40) | LMNAPPARGALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |