Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | FPR2 | P25090 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291735 | 0.84 | ULK1 (0.57) | ULK1FLT3MAPTPTPN2PTPN1 | |
| SCHEMBL20038302 | 0.84 | ULK1 (0.51) | ULK1FLT3MAPTPTPN2PTPN1 | |
| SCHEMBL20249460 | 0.83 | FLT3 (0.55) | ULK1FLT3MAPTPTPN2PTPN1 | |
| SCHEMBL26094393 | 0.83 | KMT2A (0.53) | ULK1MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL13144615 | 0.81 | ALDH1A1 (0.58) | ULK1FLT3MAPTALDH1A1SIRT2 | |
| SCHEMBL26944401 | 0.81 | ALDH1A1 (0.54) | MAPTPTPN2PTPN1ALDH1A1NPSR1 | |
| SCHEMBL16880173 | 0.80 | NAMPT (0.51) | ULK1FLT3MAPTPTPN2PTPN1 | |
| SCHEMBL1554136 | 0.79 | GSK3B (0.60) | ULK1SIRT2NPC1RAB9AABL1 | |
| SCHEMBL10195757 | 0.79 | MEN1 (0.59) | ULK1ALDH1A1NPC1RAB9ANPSR1 | |
| SCHEMBL4677821 | 0.78 | KMT2A (0.63) | ULK1FLT3PTPN1SIRT2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |