Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP1 | P63208 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | FEN1 | P39748 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA1 | P00915 | 3/20 | 0.35 |
| ▸ | CA2 | P00918 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.35 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18291733 | 0.79 | PPIB (0.38) | CKS1BSKP1SKP2ALOX5APFEN1 | |
| SCHEMBL1998123 | 0.79 | CKS1B (0.53) | CKS1BSKP1SKP2ALOX5APFEN1 | |
| SCHEMBL18291710 | 0.73 | CA1 (0.38) | CKS1BSKP1SKP2ALOX5APFEN1 | |
| SCHEMBL18291720 | 0.73 | CA12 (0.36) | CKS1BSKP1SKP2ALOX5APFEN1 | |
| SCHEMBL30517227 | 0.72 | L3MBTL1 (0.52) | CA1CA2 | |
| SCHEMBL1432994 | 0.72 | L3MBTL1 (0.52) | CA1CA2 | |
| SCHEMBL1097834 | 0.72 | PAX8 (0.44) | — | |
| SCHEMBL18650574 | 0.71 | PTPRB (0.34) | AAK1CA1CA2CA9MAPKAPK2 | |
| SCHEMBL22499289 | 0.70 | CA2 (0.50) | CA12CA1CA2CA9 | |
| SCHEMBL22174752 | 0.69 | BCHE (0.46) | ALOX5APFEN1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |