Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24747253 | 0.86 | VNN1 (0.42) | LRRK2ALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL18053868 | 0.81 | PIK3CA (0.49) | CYP11B1CYP11B2PRMT5PIK3CAMTOR | |
| SCHEMBL20038068 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2PRMT5LRRK2PIK3CA | |
| SCHEMBL24745808 | 0.81 | CHRNB2 (0.42) | LRRK2ELANECHRNB2CHRNA4CHRNB4 | |
| SCHEMBL23103355 | 0.81 | PRMT5 (0.41) | CYP11B1CYP11B2PRMT5LRRK2PIK3CA | |
| SCHEMBL23108897 | 0.81 | PRMT5 (0.46) | CYP11B1CYP11B2PRMT5LRRK2PIK3CA | |
| SCHEMBL20249241 | 0.81 | CYP11B1 (0.40) | CYP11B1CYP11B2PRMT5LRRK2PIK3CA | |
| SCHEMBL17207204 | 0.80 | ELANE (0.41) | ELANEPIK3CAMTORALDH1A1MAPT | |
| SCHEMBL14930376 | 0.80 | MAPT (0.39) | LRRK2ELANEALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL17664588 | 0.79 | ELANE (0.41) | ELANEJAK2JAK1AOC3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |