Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 8/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037582 | 0.86 | CYP11B1 (0.43) | LRRK2ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL255401 | 0.84 | MAPT (0.55) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL20092040 | 0.82 | PIK3CA (0.43) | LRRK2ALDH1A1MAPTHSD17B10POLB | |
| SCHEMBL23107822 | 0.81 | MAPT (0.44) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL24745807 | 0.81 | VNN1 (0.39) | VNN1LRRK2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL12595116 | 0.80 | LGMN (0.45) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18053622 | 0.80 | JAK2 (0.39) | ALDH1A1MAPTSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL24745808 | 0.80 | CHRNB2 (0.42) | LRRK2 | |
| SCHEMBL17207204 | 0.79 | ELANE (0.41) | ALDH1A1MAPTSMN1; SMN2RAB9AAOC3 | |
| SCHEMBL17664588 | 0.78 | ELANE (0.41) | AOC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022174253-A1 | HPK1 ANTAGONISTS AND USES THEREOF | Nimbus Saturn, Inc. (US) | 2022-08-18 | — | — | WO | disclosed |