Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK6 | Q00534 | 6/20 | 0.44 |
| ▸ | CDK4 | P11802 | 3/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CCND3 | P30281 | 1/20 | 0.44 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038605 | 0.87 | ALDH1A1 (0.50) | CDK4METTL3HRH3CCND1MEN1 | |
| SCHEMBL20037430 | 0.85 | ALDH1A1 (0.51) | CDK6CDK4CCND3CCND1MEN1 | |
| SCHEMBL23296201 | 0.82 | CDK6 (0.51) | CDK6CDK4CDK1CCNA2CCND3 | |
| SCHEMBL18291395 | 0.82 | HRH3 (0.43) | HRH3MEN1KMT2AATM | |
| SCHEMBL17828163 | 0.79 | HRH3 (0.55) | METTL3HRH3KMT2AKDRSSTR5 | |
| SCHEMBL20037687 | 0.79 | MEN1 (0.67) | HRH3MEN1KMT2AATMKDR | |
| SCHEMBL20037730 | 0.79 | METTL3 (0.42) | CDK6CDK4METTL3HRH3CCND1 | |
| SCHEMBL20037948 | 0.79 | HRH3 (0.43) | CDK6CDK4CDK1CCNA2CCND3 | |
| SCHEMBL18291475 | 0.79 | HRH3 (0.43) | CDK6CDK4CDK1CCNA2CCND3 | |
| SCHEMBL18823130 | 0.79 | TRPV6 (0.51) | HRH3MEN1KMT2AATMKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |