Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | USP25 | Q9UHP3 | 2/20 | 0.38 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20038082 | 0.80 | OPRM1 (0.44) | CHRNB2CHRNA4OPRM1USP25USP28 | |
| SCHEMBL17796315 | 0.80 | MTOR (0.46) | CHRNB2CHRNA4PIK3CAMTOR | |
| SCHEMBL611573 | 0.79 | OPRM1 (0.45) | CHRNB2CHRNA4OPRM1PIK3CAMTOR | |
| SCHEMBL23089115 | 0.79 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORROCK2 | |
| SCHEMBL23089117 | 0.79 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORROCK2 | |
| SCHEMBL23089116 | 0.79 | CHRNB2 (0.44) | CHRNB2CHRNA4PIK3CAMTORROCK2 | |
| SCHEMBL23215232 | 0.76 | HTR2A (0.42) | CHRNB2CHRNA4OPRM1CHRNB4CHRNA3 | |
| SCHEMBL20249258 | 0.76 | OPRM1 (0.41) | CHRNB2CHRNA4OPRM1USP25USP28 | |
| SCHEMBL18291649 | 0.76 | OPRM1 (0.41) | OPRM1USP25USP28ROCK2ROCK1 | |
| SCHEMBL31111805 | 0.76 | MAPK14 (0.39) | CHRNB2CHRNA4OPRM1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3305785-A1 | PYRIDO[3,4-d]PYRIMIDINE DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Teijin Pharma Limited (JP) | 2018-04-11 | — | — | EP | disclosed |