Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20037601 | 0.76 | CHRNB2 (0.49) | PIM1OPRM1CHRNB2CHRNA4 | |
| SCHEMBL31106268 | 0.75 | HRH3 (0.56) | PIM1HRH3CDK1CDK2CHRNB2 | |
| SCHEMBL31112078 | 0.72 | MAPK14 (0.47) | MAPK14MAPK13CSNK1DMAPK12MAPK11 | |
| SCHEMBL20038082 | 0.70 | OPRM1 (0.44) | OPRM1CHRNB2CHRNA7CHRNA4 | |
| SCHEMBL31106279 | 0.69 | HRH3 (0.46) | MAPK14MAPK13CSNK1DMAPK12MAPK11 | |
| SCHEMBL28676973 | 0.69 | HRH3 (0.46) | MAPK14MAPK13CSNK1DMAPK12MAPK11 | |
| SCHEMBL29515034 | 0.69 | CHEK1 (0.43) | HRH3CDK2 | |
| SCHEMBL23215232 | 0.67 | HTR2A (0.42) | OPRM1CHRNB2CHRNA4 | |
| SCHEMBL20249258 | 0.67 | OPRM1 (0.41) | RETOPRM1CHRNB2CHRNA4 | |
| SCHEMBL18291649 | 0.67 | OPRM1 (0.41) | RETHRH3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024227104-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADING BRAF VIA UBIQUITIN PROTEOSOME PATHWAY | NURIX THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |