Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RHEB | Q15382 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997410 | 0.94 | MAPT (0.36) | MAPTPPARGHSD17B10MEN1CYP3A4 | |
| SCHEMBL2002667 | 0.93 | MEN1 (0.42) | MAPTMEN1KMT2ARHEBP2RX3 | |
| SCHEMBL1999518 | 0.91 | MAPT (0.43) | MAPTPPARGHSD17B10MEN1CYP3A4 | |
| SCHEMBL1999738 | 0.91 | CYP2C9 (0.39) | MAPTCYP3A4TSHRALOX12KMT2A | |
| SCHEMBL2007743 | 0.90 | DRD2 (0.40) | MAPTMEN1CYP3A4KMT2AALDH1A1 | |
| SCHEMBL2003672 | 0.90 | KMT2A (0.45) | MAPTMEN1CYP3A4TSHRKMT2A | |
| SCHEMBL2002184 | 0.89 | PTGES2 (0.41) | MAPTPPARGHSD17B10MEN1CYP3A4 | |
| SCHEMBL2003734 | 0.89 | ALOX5AP (0.42) | MAPTHSD17B10MEN1CYP3A4TSHR | |
| SCHEMBL2002572 | 0.88 | HSD17B10 (0.36) | MAPTPPARGHSD17B10MEN1CYP3A4 | |
| SCHEMBL2007854 | 0.87 | FAAH (0.35) | MAPTPPARGHSD17B10MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7960544-B2 | Useful indole compounds | IRONWOOD PHARMACEUTICALS, INC. (US) | 2011-06-14 | — | — | US | disclosed |